|Chicken legs, old man? Must have been too much antioxidants ;-)|
The elderly subjects in the latest study from the University of Agder in Norway (Bjornson. 2015), however, don't exactly belong to the group of people I was thinking about, when I phrased this hypothesis.
In said study, thirty-four elderly males (60–81 years) were randomized to either an antioxidant group (500 mg of vitamin C and 117.5 mg vitamin E before and after training) or a placebo group. Needless to say that both groups adhered to the same standardized strength training program.
The number of sets per exercise was increased progressively from 1 to 4 sets during the first 10 weeks, and then reduced with one set each of the last 2 weeks of the intervention (tapering).
|Health and longevity as a function of mitochondrial reactive oxygen species (ROS) formation (learn more)|
Update: In fact, the ill effects of NAC specifically have - as you may have read in the 12+ Facebook news I post per day - been confirmed recently, a study that showed a 5.9% (p<0.05) reduction in insulin sensitivity compared to a non-supplemented control group (Trewin. 2015).
The participants conducted one additional “warm-up” set at 50% of their target weight in each exercise before the main sets started. The last set of each exercise was performed with maximal number of repetition, and if the number of repetitions exceeded the sessions target repetitions, the load was adjusted for the next week’s sessions. Two experienced instructors supervised all strength training sessions and the loads were weekly adjusted" (Bjornson. 2015 | my emphases).
At he end of the 12-week study, the changes body composition was assessed with dual-energy X-ray absorptiometry, the subjects' muscle thickness was diagnosed by ultrasound imaging and the muscle strength was measured as one-repetition maxima and the results were quite unambigous.That's a difference that reached statistical significance and despite some outliers on both sides of the "divide" and mustn't be ignored as random (P = 0.04).
|Figure 2: There are differences on the individiual level, but for the total muscle mass and the largest muscle group (the legs), there's little doubt that (a) the gains of the majority of subjects was reduced (Bjornson. 2015).|
- Bjornson et al. "Vitamin C and E supplementation blunts increases in total lean body mass in elderly men after strength training." Scandinavian Journal of Medicine & Science in Sports (2015): Early view article.
- Paulsen, Gøran, et al. "Can supplementation with vitamin C and E alter physiological adaptations to strength training?." BMC sports science, medicine and rehabilitation 6.1 (2014): 28.
- Paulsen, G., et al. "Vitamin C and E supplementation alters protein signalling after a strength training session, but not muscle growth during 10 weeks of training." The Journal of physiology 592.24 (2014b): 5391-5408.
- Ristow, Michael, et al. "Antioxidants prevent health-promoting effects of physical exercise in humans." Proceedings of the National Academy of Sciences 106.21 (2009): 8665-8670.
- Trewin, Adam James, et al. "Effect of N-acetylcysteine infusion on exercise induced modulation of insulin sensitivity, and signaling pathways in human skeletal muscle." American Journal of Physiology-Endocrinology and Metabolism (2015): ajpendo-00605.
- Wikipedia contributors. "Dietary Reference Intake." Wikipedia, The Free Encyclopedia. Wikipedia, The Free Encyclopedia, 23 May. 2015. Web. 2 Jul. 2015.